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KMID : 0365819690090010287
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Journal of Pusan Medical College
1969 Volume.9 No. 1 p.287 ~ p.292
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Trophoblastic Tumors
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Abstract
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This article is the clinical observation at the Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, from November 1, 1956 to May 30, 1969. A total number of 81 cases was seen with the following distribution: I-lydatidiform Mole 36, Chorioadenoma Destruens 2 and Choriocarcinoma 43.
The following features were noted among the patients with Hydatidiform Mole. Patients ranged in age from 21 to 50,of which majority was between 20-29. The average age was 32. Toxemia was seen in 30.5% of patients. Half of the patients, when first seen, had uterine enlargement greater than expected by dates. 13.9% of the patients developed theca lutein cysts. The vast majority of patients was managed by D & E, while Hysterectomies were done in 38.8;00 and Methotrexate therapies in 5.5%. 5.5 of patients developed Choriocarcinoma.
Patients with Choriocarcinoma ranged in age from 30 to 50, of which majority between 30-39. The average age was 34. 48.8% of patients developed after abortion, 32.5% after normal spontaneous vaginal delivery, 16.2% after Hydatidiform Moles, and 2.3% after Ectopic Pregnancy. 46.5% of cases showed metastatic lesions,which were found in the lung in 37.5%. vagina in 23.2%, pelvic and adnexa in 18. 6 %, and brain in 2. 3%. Patients were managed by hysterectomy in 34. 7,01o combined therapies as surgery and Chemotherapy with methotrexate in 6. 9%, chemotherapies with methotrexate alone in 6.9%. 35y, of the patients could not received any specific therapy for Choriocarcinoma. At present survival rate from 6 months to 2 years was 30%, mortality rate was 50%.
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KEYWORD
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